4RSP

X-ray structure of MERS-CoV nsp5 protease bound with a designed inhibitor

4RSP の概要

• エントリーDOI: 10.2210/pdb4rsp/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002174
• 分子名称: Orf1a protein, Peptide inhibitor (3 entities in total)
• 機能のキーワード: protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Middle East respiratory syndrome coronavirus; 詳細
• 細胞内の位置: Host cytoplasm, host perinuclear region . Host membrane ; Multi-pass membrane protein : V9TU12
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 33997.94

構造登録者

Tomar, S.,Mesecar, A.D. (登録日: 2014-11-10, 公開日: 2015-06-17, 最終更新日: 2023-12-06)

• 主引用文献: Tomar, S.,Johnston, M.L.,St John, S.E.,Osswald, H.L.,Nyalapatla, P.R.,Paul, L.N.,Ghosh, A.K.,Denison, M.R.,Mesecar, A.D.; Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS.; J.Biol.Chem., 290:19403-19422, 2015; PubMed: 26055715; DOI: 10.1074/jbc.M115.651463

実験手法

X-RAY DIFFRACTION (1.62 Å)