4RP7

Structure of the amyloid-forming segment TIITLE from p53 (residues 253-258)

4RP7 の概要

• エントリーDOI: 10.2210/pdb4rp7/pdb
• 関連するPDBエントリー: 4RP6
• 分子名称: TIITLE hexapeptide segment from p53, ZINC ION (3 entities in total)
• 機能のキーワード: p53, amyloid, fibril, amyloid-like protofibril, p53 aggregates, polymer, transcription factor, oncogene, cancer, p53 mutant, protein fibril
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 754.22

構造登録者

Soriaga, A.B.,Soragni, A.,Eisenberg, D. (登録日: 2014-10-29, 公開日: 2016-01-13, 最終更新日: 2024-02-28)

• 主引用文献: Soragni, A.,Janzen, D.M.,Johnson, L.M.,Lindgren, A.G.,Thai-Quynh Nguyen, A.,Tiourin, E.,Soriaga, A.B.,Lu, J.,Jiang, L.,Faull, K.F.,Pellegrini, M.,Memarzadeh, S.,Eisenberg, D.S.; A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas.; Cancer Cell, 29:90-103, 2016; PubMed: 26748848; DOI: 10.1016/j.ccell.2015.12.002

実験手法

X-RAY DIFFRACTION (1.576 Å)