4RNQ

Crystal structure of tobacco 5-epi-aristolochene synthase (TEAS) with anilinogeranyl diphosphate (AGPP) and geraniline

Summary for 4RNQ

Entry DOI	10.2210/pdb4rnq/pdb
Descriptor	5-epi-aristolochene synthase, MAGNESIUM ION, (2E,6E)-3,7-dimethyl-8-(phenylamino)octa-2,6-dien-1-yl trihydrogen diphosphate, ... (7 entities in total)
Functional Keywords	teas, 5-epi-aristolochene synthase, anilinogeranyl diphosphate (agpp), geraniline, terpene synthase, lyase
Biological source	Nicotiana tabacum (American tobacco,tobacco)
Cellular location	Cytoplasm: Q40577
Total number of polymer chains	1
Total formula weight	64140.27
Authors	Koo, H.J.,Crenshaw, C.M.,Starks, C.,Spielmann, H.P.,Chappell, J.,Noel, J.P. (deposition date: 2014-10-24, release date: 2015-05-06, Last modification date: 2024-02-28)
Primary citation	Rising, K.A.,Crenshaw, C.M.,Koo, H.J.,Subramanian, T.,Chehade, K.A.,Starks, C.,Allen, K.D.,Andres, D.A.,Spielmann, H.P.,Noel, J.P.,Chappell, J. Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase. Acs Chem.Biol., 10:1729-1736, 2015 Cited by PubMed: 25897591 DOI: 10.1021/acschembio.5b00145 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.47 Å)

Structure validation