4RN4

Human Carbonic anhydrases II in complex with a acetazolamide derivative comprising one hydrophobic and one hydrophilic tail moiety

4RN4 の概要

• エントリーDOI: 10.2210/pdb4rn4/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, FORMIC ACID, ... (6 entities in total)
• 機能のキーワード: carbonic anhydrase, acetazolamide, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30073.19

構造登録者

Ren, B.,Tanpure, R.,Peat, T.S.,Bornaghi, L.F.,Vullo, D.,Supuran, C.T.,Poulsen, S. (登録日: 2014-10-22, 公開日: 2015-01-28, 最終更新日: 2024-02-28)

• 主引用文献: Tanpure, R.P.,Ren, B.,Peat, T.S.,Bornaghi, L.F.,Vullo, D.,Supuran, C.T.,Poulsen, S.A.; Carbonic anhydrase inhibitors with dual-tail moieties to match the hydrophobic and hydrophilic halves of the carbonic anhydrase active site.; J.Med.Chem., 58:1494-1501, 2015; PubMed: 25581127; DOI: 10.1021/jm501798g

実験手法

X-RAY DIFFRACTION (1.53 Å)