4RLU

Crystal Structure of (3R)-hydroxyacyl-ACP dehydratase HadAB hetero-dimer from Mycobacterium tuberculosis complexed with 2',4,4'-trihydroxychalcone

Summary for 4RLU

• Entry DOI: 10.2210/pdb4rlu/pdb
• Related: 4RLJ 4RLT 4RLW
• Descriptor: (3R)-hydroxyacyl-ACP dehydratase subunit HadA, (3R)-hydroxyacyl-ACP dehydratase subunit HadB, 2',4,4'-TRIHYDROXYCHALCONE, ... (6 entities in total)
• Functional Keywords: double hotdog fold, (3r)-hydroxyacyl-acp binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Mycobacterium tuberculosis H37Rv; More
• Total number of polymer chains: 2
• Total formula weight: 33475.53

Authors

Li, J.,Dong, Y.,Rao, Z.H. (deposition date: 2014-10-18, release date: 2015-10-21, Last modification date: 2023-09-20)

• Primary citation: Dong, Y.,Qiu, X.,Shaw, N.,Xu, Y.,Sun, Y.,Li, X.,Li, J.,Rao, Z.; Molecular basis for the inhibition of beta-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors.; Protein Cell, 6:504-517, 2015; PubMed: 26081470; DOI: 10.1007/s13238-015-0181-1

Experimental method

X-RAY DIFFRACTION (2.198 Å)