4RLT

Crystal Structure of (3R)-hydroxyacyl-ACP dehydratase HadAB hetero-dimer from Mycobacterium tuberculosis complexed with Fisetin

4RLT の概要

• エントリーDOI: 10.2210/pdb4rlt/pdb
• 関連するPDBエントリー: 4RLJ 4RLU 4RLW
• 分子名称: (3R)-hydroxyacyl-ACP dehydratase subunit HadA, (3R)-hydroxyacyl-ACP dehydratase subunit HadB, 3,7,3',4'-TETRAHYDROXYFLAVONE, ... (5 entities in total)
• 機能のキーワード: double hotdog fold, (3r)-hydroxyacyl-acp binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Mycobacterium tuberculosis H37Rv; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 33297.26

構造登録者

Li, J.,Dong, Y.,Rao, Z.H. (登録日: 2014-10-18, 公開日: 2015-10-21, 最終更新日: 2023-09-20)

• 主引用文献: Dong, Y.,Qiu, X.,Shaw, N.,Xu, Y.,Sun, Y.,Li, X.,Li, J.,Rao, Z.; Molecular basis for the inhibition of beta-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors.; Protein Cell, 6:504-517, 2015; PubMed: 26081470; DOI: 10.1007/s13238-015-0181-1

実験手法

X-RAY DIFFRACTION (2.049 Å)