4RLP
Human p70s6k1 with ruthenium-based inhibitor FL772
Summary for 4RLP
Entry DOI | 10.2210/pdb4rlp/pdb |
Related | 4RLO |
Descriptor | p70S6K1, [(amino-kappaN)methanethiolato](3-fluoro-9-methoxypyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H,12H)-dionato-kappa~2~N,N')(N-methyl-1,4,7-trithiecan-9-amine-kappa~3~S~1~,S~4~,S~7~)ruthenium, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell junction, synapse, synaptosome . Isoform Alpha I: Nucleus. Isoform Alpha II: Cytoplasm: P23443 |
Total number of polymer chains | 1 |
Total formula weight | 33623.92 |
Authors | Domsic, J.F.,Barber-Rotenberg, J.,Salami, J.,Qin, J.,Marmorstein, R. (deposition date: 2014-10-17, release date: 2015-01-21, Last modification date: 2023-09-20) |
Primary citation | Qin, J.,Rajaratnam, R.,Feng, L.,Salami, J.,Barber-Rotenberg, J.S.,Domsic, J.,Reyes-Uribe, P.,Liu, H.,Dang, W.,Berger, S.L.,Villanueva, J.,Meggers, E.,Marmorstein, R. Development of Organometallic S6K1 Inhibitors. J.Med.Chem., 58:305-314, 2015 Cited by PubMed: 25356520DOI: 10.1021/jm5011868 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.79 Å) |
Structure validation
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