4RLO

Human p70s6k1 with ruthenium-based inhibitor EM5

Summary for 4RLO

• Entry DOI: 10.2210/pdb4rlo/pdb
• Related: 4RLP
• Descriptor: Ribosomal protein S6 kinase beta-1, [(amino-kappaN)methanethiolato](3-fluoro-9-hydroxypyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H,12H)-dionato-kappa~2~N,N')(1,4,7-trithionane-kappa~3~S~1~,S~4~,S~7~)ruthenium, GLYCEROL, ... (8 entities in total)
• Functional Keywords: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cell junction, synapse, synaptosome . Isoform Alpha I: Nucleus. Isoform Alpha II: Cytoplasm: P23443
• Total number of polymer chains: 2
• Total formula weight: 67271.23

Authors

Domsic, J.F.,Barber-Rotenberg, J.,Salami, J.,Qin, J.,Marmorstein, R. (deposition date: 2014-10-17, release date: 2015-01-21, Last modification date: 2023-09-20)

• Primary citation: Qin, J.,Rajaratnam, R.,Feng, L.,Salami, J.,Barber-Rotenberg, J.S.,Domsic, J.,Reyes-Uribe, P.,Liu, H.,Dang, W.,Berger, S.L.,Villanueva, J.,Meggers, E.,Marmorstein, R.; Development of Organometallic S6K1 Inhibitors.; J.Med.Chem., 58:305-314, 2015; PubMed: 25356520; DOI: 10.1021/jm5011868

Experimental method

X-RAY DIFFRACTION (2.527 Å)