4RLL
Crystal structure of human CK2alpha in complex with the ATP-competitive inhibitor 4-[(E)-(fluoren-9-ylidenehydrazinylidene)-methyl] benzoate
Summary for 4RLL
Entry DOI | 10.2210/pdb4rll/pdb |
Related | 4RLK |
Descriptor | Casein kinase II subunit alpha, GLYCEROL, 4-[(E)-(9H-fluoren-9-ylidenehydrazinylidene)methyl]benzoic acid, ... (4 entities in total) |
Functional Keywords | transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 40485.18 |
Authors | Guerra, B.,Rasmussen, T.D.L.,Schnitzler, A.,Jensen, H.H.,Boldyreff, B.S.,Miyata, Y.,Marcussen, N.,Niefind, K.,Issinger, O.G. (deposition date: 2014-10-17, release date: 2014-12-17, Last modification date: 2023-09-20) |
Primary citation | Guerra, B.,Rasmussen, T.D.,Schnitzler, A.,Jensen, H.H.,Boldyreff, B.S.,Miyata, Y.,Marcussen, N.,Niefind, K.,Issinger, O.G. Protein kinase CK2 inhibition is associated with the destabilization of HIF-1 alpha in human cancer cells. Cancer Lett, 356:751-761, 2015 Cited by PubMed: 25449433DOI: 10.1016/j.canlet.2014.10.026 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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