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4RJ7

EGFR kinase (T790M/L858R) with inhibitor compound 1

Summary for 4RJ7
Entry DOI10.2210/pdb4rj7/pdb
Related4RJ3 4RJ4 4RJ5 4RJ6 4RJ8
DescriptorEpidermal growth factor receptor, SULFATE ION, 2,6-dichloro-N-{2-[(2-{[(2S)-1-hydroxypropan-2-yl]amino}-6-methylpyrimidin-4-yl)amino]pyridin-4-yl}benzamide, ... (4 entities in total)
Functional Keywordsprotein kinase, phosphotransfer catalyst, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains1
Total formula weight38092.78
Authors
Eigenbrot, C.,Yu, C. (deposition date: 2014-10-08, release date: 2014-11-26, Last modification date: 2023-09-20)
Primary citationHanan, E.J.,Eigenbrot, C.,Bryan, M.C.,Burdick, D.J.,Chan, B.K.,Chen, Y.,Dotson, J.,Heald, R.A.,Jackson, P.S.,La, H.,Lainchbury, M.D.,Malek, S.,Purkey, H.E.,Schaefer, G.,Schmidt, S.,Seward, E.M.,Sideris, S.,Tam, C.,Wang, S.,Yeap, S.K.,Yen, I.,Yin, J.,Yu, C.,Zilberleyb, I.,Heffron, T.P.
Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation.
J.Med.Chem., 57:10176-10191, 2014
Cited by
PubMed: 25383627
DOI: 10.1021/jm501578n
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.55 Å)
Structure validation

217705

건을2024-03-27부터공개중

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