4RIR

Structural Analysis of the Unmutated Ancestor of the HIV-1 Envelope V2 Region Antibody CH58 Isolated From an RV144 HIV-1 Vaccine Efficacy Trial Vaccinee and Associated with Decreased Transmission Risk

4RIR の概要

• エントリーDOI: 10.2210/pdb4rir/pdb
• 関連するPDBエントリー: 4RIS
• 分子名称: CH58-UA Fab heavy chain, CH58-UA Fab light chain (3 entities in total)
• 機能のキーワード: antibody, igg fold, immune system, hiv-1 gp120 v2 region
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 96240.53

構造登録者

Nicely, N.I.,Wiehe, K.,Kepler, T.B.,Jaeger, F.H.,Dennison, S.M.,Liao, H.-X.,Alam, S.M.,Hwang, K.-K.,Bonsignori, M.,Rerks-Ngarm, S.,Nitayaphan, S.,Pitisuttithum, P.,Kaewkungwal, J.,Robb, M.L.,O'Connell, R.J.,Michael, N.L.,Kim, J.H.,Haynes, B.F. (登録日: 2014-10-07, 公開日: 2015-08-12, 最終更新日: 2015-09-02)

• 主引用文献: Nicely, N.I.,Wiehe, K.,Kepler, T.B.,Jaeger, F.H.,Dennison, S.M.,Rerks-Ngarm, S.,Nitayaphan, S.,Pitisuttithum, P.,Kaewkungwal, J.,Robb, M.L.,O'Connell, R.J.,Michael, N.L.,Kim, J.H.,Liao, H.X.,Munir Alam, S.,Hwang, K.K.,Bonsignori, M.,Haynes, B.F.; Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee.; EBioMedicine, 2:713-722, 2015; PubMed: 26288844; DOI: 10.1016/j.ebiom.2015.06.016

実験手法

X-RAY DIFFRACTION (2.5 Å)