4RIO
Crystal structure of JAK3 kinase domain in complex with a pyrrolopyridazine carboxamide inhibitor
Summary for 4RIO
Entry DOI | 10.2210/pdb4rio/pdb |
Descriptor | Tyrosine-protein kinase JAK3, 4-{[(1R,2S)-2-fluoro-2-methylcyclopentyl]amino}pyrrolo[1,2-b]pyridazine-3-carboxamide (3 entities in total) |
Functional Keywords | transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Endomembrane system ; Peripheral membrane protein : P52333 |
Total number of polymer chains | 1 |
Total formula weight | 33530.33 |
Authors | Sack, J.S. (deposition date: 2014-10-07, release date: 2014-12-24, Last modification date: 2024-02-28) |
Primary citation | Duan, J.J.,Lu, Z.,Jiang, B.,Yang, B.V.,Doweyko, L.M.,Nirschl, D.S.,Haque, L.E.,Lin, S.,Brown, G.,Hynes, J.,Tokarski, J.S.,Sack, J.S.,Khan, J.,Lippy, J.S.,Zhang, R.F.,Pitt, S.,Shen, G.,Pitts, W.J.,Carter, P.H.,Barrish, J.C.,Nadler, S.G.,Salter-Cid, L.M.,McKinnon, M.,Fura, A.,Schieven, G.L.,Wrobleski, S.T. Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors. Bioorg.Med.Chem.Lett., 24:5721-5726, 2014 Cited by PubMed: 25453808DOI: 10.1016/j.bmcl.2014.10.061 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.69 Å) |
Structure validation
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