4RFC
Human carbonic anhydrase II in complex with tert-butyl 4-(4-sulfamoylphenoxy)butylcarbamate
Summary for 4RFC
| Entry DOI | 10.2210/pdb4rfc/pdb |
| Related | 4RFD |
| Descriptor | Carbonic anhydrase 2, ZINC ION, tert-butyl 4-(4-sulfamoylphenoxy)butylcarbamate, ... (4 entities in total) |
| Functional Keywords | sulfonamide, carbonic anhydrase, antiglaucoma, o-(-aminoalkyl)-benzenesulfonamides, lyase |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm : P00918 |
| Total number of polymer chains | 1 |
| Total formula weight | 29698.90 |
| Authors | Bozdag, M.,Pinard, M.A.,Carta, F.,Masini, E.,Scozzafava, A.,Mckenna, R.,Supuran, C.T. (deposition date: 2014-09-25, release date: 2015-04-15, Last modification date: 2024-02-28) |
| Primary citation | Bozdag, M.,Pinard, M.,Carta, F.,Masini, E.,Scozzafava, A.,McKenna, R.,Supuran, C.T. A class of 4-sulfamoylphenyl-omega-aminoalkyl ethers with effective carbonic anhydrase inhibitory action and antiglaucoma effects. J.Med.Chem., 57:9673-9686, 2014 Cited by PubMed: 25358036DOI: 10.1021/jm501497m PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.645 Å) |
Structure validation
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