4RET

Crystal structure of the Na,K-ATPase E2P-digoxin complex with bound magnesium

4RET の概要

• エントリーDOI: 10.2210/pdb4ret/pdb
• 関連するPDBエントリー: 3N23 4HYT 4RES
• 関連するBIRD辞書のPRD_ID: PRD_900003
• 分子名称: Sodium/potassium-transporting ATPase subunit alpha-1, 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium/potassium-transporting ATPase subunit beta-1, ... (11 entities in total)
• 機能のキーワード: alpha-helical transmembrane protein, atpase, sodium ion transport, potassium ion transport, atp binding, sodium binding, potassium binding, receptor for cardiotonic steroids, phosphorylation, glycosylation, plasma membrane, multisubunit complex, trimeric complex, membrane protein, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Sus scrofa (pig); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 317964.44

構造登録者

Gregersen, J.L.,Laursen, M.,Yatime, L.,Nissen, P.,Fedosova, N.U. (登録日: 2014-09-23, 公開日: 2015-01-28, 最終更新日: 2023-09-20)

• 主引用文献: Laursen, M.,Gregersen, J.L.,Yatime, L.,Nissen, P.,Fedosova, N.U.; Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex.; Proc.Natl.Acad.Sci.USA, 112:1755-1760, 2015; PubMed: 25624492; DOI: 10.1073/pnas.1422997112

実験手法

X-RAY DIFFRACTION (4 Å)