4RED
Crystal structure of human AMPK alpha1 KD-AID with K43A mutation
Summary for 4RED
Entry DOI | 10.2210/pdb4red/pdb |
Descriptor | 5'-AMP-activated protein kinase catalytic subunit alpha-1 (2 entities in total) |
Functional Keywords | kinase domain fold, phosphorylate numerous cellular targets, upregulate atp-generating pathways upon activation, ampk beta and gamma subunits, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : Q13131 |
Total number of polymer chains | 2 |
Total formula weight | 80400.47 |
Authors | Zhou, X.E.,Ke, J.,Li, X.,Wang, L.,Gu, X.,de Waal, P.W.,Tan, M.H.E.,Wang, D.,Wu, D.,Xu, H.E.,Melcher, K. (deposition date: 2014-09-22, release date: 2014-12-10, Last modification date: 2023-09-20) |
Primary citation | Li, X.,Wang, L.,Zhou, X.E.,Ke, J.,de Waal, P.W.,Gu, X.,Tan, M.H.,Wang, D.,Wu, D.,Xu, H.E.,Melcher, K. Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Res., 25:50-66, 2015 Cited by PubMed: 25412657DOI: 10.1038/cr.2014.150 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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