4RED

Crystal structure of human AMPK alpha1 KD-AID with K43A mutation

Summary for 4RED

• Entry DOI: 10.2210/pdb4red/pdb
• Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1 (2 entities in total)
• Functional Keywords: kinase domain fold, phosphorylate numerous cellular targets, upregulate atp-generating pathways upon activation, ampk beta and gamma subunits, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : Q13131
• Total number of polymer chains: 2
• Total formula weight: 80400.47

Authors

Zhou, X.E.,Ke, J.,Li, X.,Wang, L.,Gu, X.,de Waal, P.W.,Tan, M.H.E.,Wang, D.,Wu, D.,Xu, H.E.,Melcher, K. (deposition date: 2014-09-22, release date: 2014-12-10, Last modification date: 2023-09-20)

• Primary citation: Li, X.,Wang, L.,Zhou, X.E.,Ke, J.,de Waal, P.W.,Gu, X.,Tan, M.H.,Wang, D.,Wu, D.,Xu, H.E.,Melcher, K.; Structural basis of AMPK regulation by adenine nucleotides and glycogen.; Cell Res., 25:50-66, 2015; PubMed: 25412657; DOI: 10.1038/cr.2014.150

Experimental method

X-RAY DIFFRACTION (2.95 Å)