4RDD
Co-crystal structure of SHP2 in complex with a Cefsulodin derivative
Summary for 4RDD
Entry DOI | 10.2210/pdb4rdd/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11, 1-({(2R)-4-carboxy-2-[(R)-carboxy{[(2R)-2-phenyl-2-sulfoacetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium (3 entities in total) |
Functional Keywords | hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q06124 |
Total number of polymer chains | 1 |
Total formula weight | 32655.06 |
Authors | Zhang, Z.Y.,Yu, Z.H.,He, R.,Zhang, R.Y. (deposition date: 2014-09-18, release date: 2015-07-01, Last modification date: 2015-12-16) |
Primary citation | He, R.,Yu, Z.H.,Zhang, R.Y.,Wu, L.,Gunawan, A.M.,Lane, B.S.,Shim, J.S.,Zeng, L.F.,He, Y.,Chen, L.,Wells, C.D.,Liu, J.O.,Zhang, Z.Y. Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors. ACS Med Chem Lett, 6:782-786, 2015 Cited by PubMed: 26191366DOI: 10.1021/acsmedchemlett.5b00118 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.601 Å) |
Structure validation
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