4RDA

X-RAY STRUCTURE OF THE AMYLOID PRECURSOR PROTEIN-LIKE PROTEIN 1 (APLP1) E2 DOMAIN IN COMPLEX WITH A HEPARIN DODECASACCHARIDE

Summary for 4RDA

• Entry DOI: 10.2210/pdb4rda/pdb
• Related: 4RD9
• Descriptor: Amyloid-like protein 1, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, ... (5 entities in total)
• Functional Keywords: heparan sulfate binding, sugar binding protein
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type I membrane protein. C30: Cytoplasm: P51693
• Total number of polymer chains: 2
• Total formula weight: 52148.05

Authors

Dahms, S.O.,Than, M.E. (deposition date: 2014-09-18, release date: 2015-03-11, Last modification date: 2024-02-28)

• Primary citation: Dahms, S.O.,Mayer, M.C.,Roeser, D.,Multhaup, G.,Than, M.E.; Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes.; Acta Crystallogr.,Sect.D, 71:494-504, 2015; PubMed: 25760599; DOI: 10.1107/S1399004714027114

Experimental method

X-RAY DIFFRACTION (2.497 Å)