4RDA

X-RAY STRUCTURE OF THE AMYLOID PRECURSOR PROTEIN-LIKE PROTEIN 1 (APLP1) E2 DOMAIN IN COMPLEX WITH A HEPARIN DODECASACCHARIDE

4RDA の概要

• エントリーDOI: 10.2210/pdb4rda/pdb
• 関連するPDBエントリー: 4RD9
• 分子名称: Amyloid-like protein 1, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, ... (5 entities in total)
• 機能のキーワード: heparan sulfate binding, sugar binding protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. C30: Cytoplasm: P51693
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 52148.05

構造登録者

Dahms, S.O.,Than, M.E. (登録日: 2014-09-18, 公開日: 2015-03-11, 最終更新日: 2024-02-28)

• 主引用文献: Dahms, S.O.,Mayer, M.C.,Roeser, D.,Multhaup, G.,Than, M.E.; Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes.; Acta Crystallogr.,Sect.D, 71:494-504, 2015; PubMed: 25760599; DOI: 10.1107/S1399004714027114

実験手法

X-RAY DIFFRACTION (2.497 Å)