4RAC

Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents

4RAC の概要

• エントリーDOI: 10.2210/pdb4rac/pdb
• 関連するPDBエントリー: 4RAB 4RAD 4RAN 4RAO 4RAQ
• 分子名称: Hypoxanthine-guanine phosphoribosyltransferase, [(2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][(E)-2-phosphonoethenyl]amino}ethoxy)methyl]phosphonic acid, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: 6-oxopurine phosphoribosyltransferase, 9-[(n-phosphonoethyl-n-phosphonomethoxyethyl)-2-aminoethyl]guanine, cytoplasmic, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P00492
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 99848.08

構造登録者

Keough, D.T.,Hockova, D.,Janeba, Z.,Wang, T.-H.,Naesens, L.,Edstein, M.D.,Chavchich, M.,Guddat, L.W. (登録日: 2014-09-10, 公開日: 2015-01-07, 最終更新日: 2024-02-28)

• 主引用文献: Keough, D.T.,Hockova, D.,Janeba, Z.,Wang, T.H.,Naesens, L.,Edstein, M.D.,Chavchich, M.,Guddat, L.W.; Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents.; J.Med.Chem., 58:827-846, 2015; PubMed: 25494538; DOI: 10.1021/jm501416t

実験手法

X-RAY DIFFRACTION (2.05 Å)