4RA4

Crystal Structure of Human Protein Kinase C Alpha in Complex with Compound 28 ((R)-6-((3S,4S)-1,3-Dimethyl-piperidin-4-yl)-7-(2-fluoro-phenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one)

4RA4 の概要

• エントリーDOI: 10.2210/pdb4ra4/pdb
• 関連するPDBエントリー: 4Q9S 4Q9Z
• 分子名称: Protein kinase C, (1R)-9-[(3S,4S)-1,3-dimethylpiperidin-4-yl]-8-(2-fluorophenyl)-1-methyl-3,5-dihydro[1,2,4]triazino[3,4-c][1,4]benzoxazin-2(1H)-one (3 entities in total)
• 機能のキーワード: kinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41269.96

構造登録者

Argiriadi, M.A.,George, D.M. (登録日: 2014-09-09, 公開日: 2014-10-08, 最終更新日: 2024-03-06)

• 主引用文献: George, D.M.,Breinlinger, E.C.,Argiriadi, M.A.,Zhang, Y.,Wang, J.,Bansal-Pakala, P.,Duignan, D.B.,Honore, P.,Lang, Q.,Mittelstadt, S.,Rundell, L.,Schwartz, A.,Sun, J.,Edmunds, J.J.; Optimized Protein Kinase C theta (PKC theta ) Inhibitors Reveal Only Modest Anti-inflammatory Efficacy in a Rodent Model of Arthritis.; J.Med.Chem., 58:333-346, 2015; PubMed: 25254961; DOI: 10.1021/jm5013006

実験手法

X-RAY DIFFRACTION (2.63 Å)