4R8I
High Resolution Structure of a Mirror-Image RNA Oligonucleotide Aptamer in Complex with the Chemokine CCL2
Summary for 4R8I
Entry DOI | 10.2210/pdb4r8i/pdb |
Descriptor | C-C motif chemokine 2, Mirror-Image RNA Oligonucleotide Aptamer NOXE36, SODIUM ION, ... (6 entities in total) |
Functional Keywords | aptamer spiegelmer l-oligonucleotide, cytokine-rna complex, cytokine/rna |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P13500 |
Total number of polymer chains | 2 |
Total formula weight | 22046.99 |
Authors | Oberthuer, D.,Achenbach, J.,Gabdulkhakov, A.,Falke, S.,Buchner, K.,Maasch, C.,Rehders, D.,Klussmann, S.,Betzel, C. (deposition date: 2014-09-02, release date: 2015-04-29, Last modification date: 2015-05-06) |
Primary citation | Oberthur, D.,Achenbach, J.,Gabdulkhakov, A.,Buchner, K.,Maasch, C.,Falke, S.,Rehders, D.,Klussmann, S.,Betzel, C. Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2. Nat Commun, 6:6923-6923, 2015 Cited by PubMed: 25901662DOI: 10.1038/ncomms7923 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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