4R8I

High Resolution Structure of a Mirror-Image RNA Oligonucleotide Aptamer in Complex with the Chemokine CCL2

4R8I の概要

• エントリーDOI: 10.2210/pdb4r8i/pdb
• 分子名称: C-C motif chemokine 2, Mirror-Image RNA Oligonucleotide Aptamer NOXE36, SODIUM ION, ... (6 entities in total)
• 機能のキーワード: aptamer spiegelmer l-oligonucleotide, cytokine-rna complex, cytokine/rna
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P13500
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22046.99

構造登録者

Oberthuer, D.,Achenbach, J.,Gabdulkhakov, A.,Falke, S.,Buchner, K.,Maasch, C.,Rehders, D.,Klussmann, S.,Betzel, C. (登録日: 2014-09-02, 公開日: 2015-04-29, 最終更新日: 2015-05-06)

• 主引用文献: Oberthur, D.,Achenbach, J.,Gabdulkhakov, A.,Buchner, K.,Maasch, C.,Falke, S.,Rehders, D.,Klussmann, S.,Betzel, C.; Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2.; Nat Commun, 6:6923-6923, 2015; PubMed: 25901662; DOI: 10.1038/ncomms7923

実験手法

X-RAY DIFFRACTION (2.05 Å)