4R6U

IL-18 receptor complex

Summary for 4R6U

• Entry DOI: 10.2210/pdb4r6u/pdb
• Descriptor: Interleukin-18 receptor 1, Interleukin-18, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: beta-trefoil fold, ig-like fold, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 111411.64

Authors

Wei, H.,Wang, X. (deposition date: 2014-08-26, release date: 2014-10-15, Last modification date: 2024-11-06)

Primary citation

Wei, H.,Wang, D.,Qian, Y.,Liu, X.,Fan, S.,Yin, H.S.,Wang, X.
Structural basis for the specific recognition of IL-18 by its alpha receptor.
Febs Lett., 588:3838-3843, 2014

PubMed Abstract: Interleukin 18 (IL-18), a member of the IL-1 family of cytokines, is an important regulator of innate and acquired immune responses. It signals through its ligand-binding primary receptor IL-18Rα and accessory receptor IL-18Rβ. Here we report the crystal structure of IL-18 with the ectodomain of IL-18Rα, which reveals the structural basis for their specific recognition. It confirms that surface charge complementarity determines the ligand-binding specificity of primary receptors in the IL-1 receptor family. We suggest that IL-18 signaling complex adopts an architecture similar to other agonistic cytokines and propose a general ligand-receptor assembly and activation model for the IL-1 family.

PubMed: 25261253
DOI: 10.1016/j.febslet.2014.09.019

Experimental method

X-RAY DIFFRACTION (2.8 Å)