4R6A

Crystal structure of human TLR8 in complex with Hybrid-2

4R6A の概要

• エントリーDOI: 10.2210/pdb4r6a/pdb
• 分子名称: Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: rna recognition, ssrna, leucine rich repeat, rna receptor, innate immunity, glycosylation, secreted, structure-based ligand design, vaccine adjuvants, antiviral and antitumor drug binding, rna binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 192351.16

構造登録者

Tanji, H.,Ohto, U.,Shimizu, T. (登録日: 2014-08-22, 公開日: 2015-08-26, 最終更新日: 2020-07-29)

• 主引用文献: Ganapathi, L.,Haren, S.V.,Dowling, D.J.,Bergelson, I.,Shukla, N.M.,Malladi, S.S.,Balakrishna, R.,Tanji, H.,Ohto, U.,Shimizu, T.,David, S.A.,Levy, O.; Hybrid-2: AnImidazoquinoline Dual Toll-like receptor 7/8 Agonist that Potently Activates Cytokine Production by Human Newborn and Adult Leukocytes; To be Published,

実験手法

X-RAY DIFFRACTION (2.1 Å)