4R5S

Crystal structure of EGFR 696-1022 L858R in complex with FIIN-3

4R5S の概要

• エントリーDOI: 10.2210/pdb4r5s/pdb
• 分子名称: Epidermal growth factor receptor, N-[4-({[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino}methyl)phenyl]propanamide (3 entities in total)
• 機能のキーワード: egfr, l858r, kinase, fiin-3, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38370.11

構造登録者

Zhu, S.J.,Yun, C.H. (登録日: 2014-08-22, 公開日: 2014-11-12, 最終更新日: 2022-08-24)

• 主引用文献: Tan, L.,Wang, J.,Tanizaki, J.,Huang, Z.,Aref, A.R.,Rusan, M.,Zhu, S.J.,Zhang, Y.,Ercan, D.,Liao, R.G.,Capelletti, M.,Zhou, W.,Hur, W.,Kim, N.,Sim, T.,Gaudet, S.,Barbie, D.A.,Yeh, J.R.,Yun, C.H.,Hammerman, P.S.,Mohammadi, M.,Janne, P.A.,Gray, N.S.; Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.; Proc.Natl.Acad.Sci.USA, 111:E4869-E4877, 2014; PubMed: 25349422; DOI: 10.1073/pnas.1403438111

実験手法

X-RAY DIFFRACTION (3.001 Å)