4R4O

Crystal structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran-2-yl)benzyl)carbamothioyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid

4R4O の概要

• エントリーDOI: 10.2210/pdb4r4o/pdb
• 関連するPDBエントリー: 4R4C 4R4I 4R4Q 4R4T
• 分子名称: Replication protein A 70 kDa DNA-binding subunit, 5-(4-{[4-(5-carboxyfuran-2-yl)benzyl]carbamothioyl}phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid (3 entities in total)
• 機能のキーワード: ob-fold, protein-protein interaction, protein binding
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : P27694
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14090.18

構造登録者

Feldkamp, M.D.,Waterson, A.G.,Kennedy, J.P.,Patrone, J.D.,Pelz, N.F.,Frank, A.O.,Vangamudi, B.,Sousa-Fagundes, E.M.,Rossanese, O.W.,Fesik, S.W.,Chazin, W.J. (登録日: 2014-08-19, 公開日: 2014-11-19, 最終更新日: 2023-09-20)

• 主引用文献: Waterson, A.G.,Kennedy, J.P.,Patrone, J.D.,Pelz, N.F.,Feldkamp, M.D.,Frank, A.O.,Vangamudi, B.,Souza-Fagundes, E.M.,Rossanese, O.W.,Chazin, W.J.,Fesik, S.W.; Diphenylpyrazoles as replication protein a inhibitors.; ACS Med Chem Lett, 6:140-145, 2015; PubMed: 25699140; DOI: 10.1021/ml5003629

実験手法

X-RAY DIFFRACTION (1.33 Å)