4R3R

Crystal structures of EGFR in complex with Mig6

Summary for 4R3R

• Entry DOI: 10.2210/pdb4r3r/pdb
• Related: 4R3P
• Descriptor: Epidermal growth factor receptor, peptide from ERBB receptor feedback inhibitor 1' (3 entities in total)
• Functional Keywords: kinase, phophorylation, atp hydrolysis, mig6, phosphorylation, transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533; Cytoplasm : Q9UJM3
• Total number of polymer chains: 2
• Total formula weight: 38004.74

Authors

Park, E.,Kim, N.,Yi, Z.,Cho, A.,Kim, K.,Ficarro, S.B.,Park, A.,Park, W.Y.,Murray, B.,Meyerson, M.,Beroukim, R.,Marto, J.A.,Cho, J.,Eck, M.J. (deposition date: 2014-08-17, release date: 2015-08-12, Last modification date: 2015-09-16)

• Primary citation: Park, E.,Kim, N.,Ficarro, S.B.,Zhang, Y.,Lee, B.I.,Cho, A.,Kim, K.,Park, A.K.,Park, W.Y.,Murray, B.,Meyerson, M.,Beroukhim, R.,Marto, J.A.,Cho, J.,Eck, M.J.; Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.; Nat.Struct.Mol.Biol., 22:703-711, 2015; PubMed: 26280531; DOI: 10.1038/nsmb.3074

Experimental method

X-RAY DIFFRACTION (3.25 Å)