4R3C

Crystal structure of p38 alpha MAP kinase in complex with a novel isoform selective drug candidate

4R3C の概要

• エントリーDOI: 10.2210/pdb4r3c/pdb
• 関連するPDBエントリー: 4EWQ 4F9W 4F9Y
• 分子名称: Mitogen-activated protein kinase 14, 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, 6-(4-methylpiperazin-1-yl)-3-(naphthalen-2-yl)-4-(pyridin-4-yl)pyridazine, ... (5 entities in total)
• 機能のキーワード: serine/threonine-protein kinase, protein kinase domain, transferase, atp binding, phosphorylation, cytosol, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45069.67

構造登録者

Grum-Tokars, V.L.,Minasov, G.,Roy, S.M.,Anderson, W.F.,Watterson, D.M. (登録日: 2014-08-14, 公開日: 2015-02-25, 最終更新日: 2017-11-22)

• 主引用文献: Roy, S.M.,Grum-Tokars, V.L.,Schavocky, J.P.,Saeed, F.,Staniszewski, A.,Teich, A.F.,Arancio, O.,Bachstetter, A.D.,Webster, S.J.,Van Eldik, L.J.,Minasov, G.,Anderson, W.F.,Pelletier, J.C.,Watterson, D.M.; Targeting human central nervous system protein kinases: An isoform selective p38 alpha MAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models.; ACS Chem Neurosci, 6:666-680, 2015; PubMed: 25676389; DOI: 10.1021/acschemneuro.5b00002

実験手法

X-RAY DIFFRACTION (2.06 Å)