4R3B
Crystal structure of SHV-1 b-lactamase in complex with 6b-(hydroxymethyl)penicillanic acid sulfone PSR-283A
Summary for 4R3B
Entry DOI | 10.2210/pdb4r3b/pdb |
Related | 2H4S 4FH4 |
Descriptor | Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, N-[(1E)-2-formyl-3-hydroxyprop-1-en-1-yl]-3-[(S)-sulfino]-D-valine, ... (4 entities in total) |
Functional Keywords | class a beta-lactamase, hydrolase, inactivate b-lactam antibiotics |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 30189.50 |
Authors | Rodkey, E.A.,van den Akker, F. (deposition date: 2014-08-14, release date: 2015-01-21, Last modification date: 2024-05-15) |
Primary citation | Che, T.,Rodkey, E.A.,Bethel, C.R.,Shanmugam, S.,Ding, Z.,Pusztai-Carey, M.,Nottingham, M.,Chai, W.,Buynak, J.D.,Bonomo, R.A.,van den Akker, F.,Carey, P.R. Detecting a Quasi-stable Imine Species on the Reaction Pathway of SHV-1 beta-Lactamase and 6 beta-(Hydroxymethyl)penicillanic Acid Sulfone. Biochemistry, 54:734-743, 2015 Cited by PubMed: 25536850DOI: 10.1021/bi501197t PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.366 Å) |
Structure validation
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