4R20

Zebra fish cytochrome P450 17A2 with Abiraterone

Summary for 4R20

• Entry DOI: 10.2210/pdb4r20/pdb
• Related: 4R1Z 4R21
• Descriptor: Cytochrome P450 family 17 polypeptide 2, PROTOPORPHYRIN IX CONTAINING FE, Abiraterone, ... (5 entities in total)
• Functional Keywords: abiraterone, zebrafish, p450 17a1, 17(alpha)-hydroylation, lysase reaction, steroid biosynthesis, enzyme kinetics, oxidoreductase
• Biological source: Danio rerio (leopard danio,zebra danio,zebra fish)
• Total number of polymer chains: 2
• Total formula weight: 111227.25

Authors

Pallan, P.S.,Egli, M. (deposition date: 2014-08-08, release date: 2014-12-31, Last modification date: 2024-02-28)

• Primary citation: Pallan, P.S.,Nagy, L.D.,Lei, L.,Gonzalez, E.,Kramlinger, V.M.,Azumaya, C.M.,Wawrzak, Z.,Waterman, M.R.,Guengerich, F.P.,Egli, M.; Structural and Kinetic Basis of Steroid 17 alpha, 20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2.; J.Biol.Chem., 290:3248-3268, 2015; PubMed: 25533464; DOI: 10.1074/jbc.M114.627265

Experimental method

X-RAY DIFFRACTION (2.86 Å)