4R1E

Crystal Structure of MTIP from Plasmodium falciparum in complex with a peptide-fragment chimera

4R1E の概要

• エントリーDOI: 10.2210/pdb4r1e/pdb
• 関連するPDBエントリー: 4AOM 4MZJ 4MZK 4MZL
• 分子名称: Myosin A tail domain interacting protein, Myosin-A, 5-{[(2-aminoethyl)sulfanyl]methyl}furan-2-carbaldehyde, ... (4 entities in total)
• 機能のキーワード: calmodulin-like, protein binding, myosin motor, fragment peptide, membrane, protein binding-inhibitor complex, protein binding/inhibitor
• 由来する生物種: Plasmodium falciparum; 詳細
• 細胞内の位置: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side : Q8IDR3
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 18424.65

構造登録者

Douse, C.H.,Vrielink, N.,Cota, E.,Tate, E.W. (登録日: 2014-08-05, 公開日: 2014-11-12, 最終更新日: 2023-09-20)

• 主引用文献: Douse, C.H.,Vrielink, N.,Wenlin, Z.,Cota, E.,Tate, E.W.; Targeting a Dynamic Protein-Protein Interaction: Fragment Screening against the Malaria Myosin A Motor Complex.; Chemmedchem, 10:134-143, 2015; PubMed: 25367834; DOI: 10.1002/cmdc.201402357

実験手法

X-RAY DIFFRACTION (1.98 Å)