4QZS

Crystal structure of the first bromodomain of human 3-fluoro tyrosine-labeled brd4 in complex with jq1

4QZS の概要

• エントリーDOI: 10.2210/pdb4qzs/pdb
• 分子名称: Bromodomain-containing protein 4, (6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: cap, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, cell cycle, inhibitor, transcription
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15842.89

構造登録者

Ember, S.W.,Schonbrunn, E. (登録日: 2014-07-28, 公開日: 2014-10-29, 最終更新日: 2023-09-20)

• 主引用文献: Mishra, N.K.,Urick, A.K.,Ember, S.W.,Schonbrunn, E.,Pomerantz, W.C.; Fluorinated aromatic amino acids are sensitive (19)f NMR probes for bromodomain-ligand interactions.; Acs Chem.Biol., 9:2755-2760, 2014; PubMed: 25290579; DOI: 10.1021/cb5007344

実験手法

X-RAY DIFFRACTION (1.45 Å)