4QYK

Crystal structure of a canine parvovirus variant

これはPDB形式変換不可エントリーです。

4QYK の概要

• エントリーDOI: 10.2210/pdb4qyk/pdb
• 分子名称: Capsid protein VP1, MAGNESIUM ION (2 entities in total)
• 機能のキーワード: capsid protein, virus
• 由来する生物種: Feline panleukopenia virus (FPV)
• タンパク質・核酸の鎖数: 30
• 化学式量合計: 1943095.92

構造登録者

Lukk, T.,Organtini, L.J.,Hafenstein, S.U. (登録日: 2014-07-24, 公開日: 2014-12-10, 最終更新日: 2024-10-30)

主引用文献

Organtini, L.J.,Allison, A.B.,Lukk, T.,Parrish, C.R.,Hafenstein, S.
Global Displacement of Canine Parvovirus by a Host-Adapted Variant: Structural Comparison between Pandemic Viruses with Distinct Host Ranges.
J.Virol., 89:1909-1912, 2015

PubMed Abstract: Canine parvovirus type 2 (CPV-2) emerged in 1978 and spread worldwide within 2 years. Subsequently, CPV-2 was completely replaced by the variant CPV-2a, which is characterized by four specific capsid (VP2) mutations. The X-ray crystal structure of the CPV-2a capsid shows that each mutation confers small local changes. The loss of a hydrogen bond and introduction of a glycine residue likely introduce flexibility to sites that control interactions with the host receptor, antibodies, and sialic acids.

PubMed: 25410876
DOI: 10.1128/JVI.02611-14

実験手法

X-RAY DIFFRACTION (3.5 Å)