4QXS

Crystal structure of human FPPS in complex with WC01088

Summary for 4QXS

Entry DOI	10.2210/pdb4qxs/pdb
Descriptor	Farnesyl pyrophosphate synthase, PHOSPHATE ION, (2-{2-[(2S)-3-methylbutan-2-yl]-5-phenyl-1H-indol-3-yl}ethane-1,1-diyl)bis(phosphonic acid), ... (5 entities in total)
Functional Keywords	transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P14324
Total number of polymer chains	1
Total formula weight	43878.41
Authors	Park, J.,Zielinski, M.,Weiling, C.,Tsantrizos, Y.S.,Berghuis, A.M. (deposition date: 2014-07-21, release date: 2015-02-25, Last modification date: 2023-09-20)
Primary citation	Gritzalis, D.,Park, J.,Chiu, W.,Cho, H.,Lin, Y.S.,De Schutter, J.W.,Lacbay, C.M.,Zielinski, M.,Berghuis, A.M.,Tsantrizos, Y.S. Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase. Bioorg.Med.Chem.Lett., 25:1117-1123, 2015 Cited by PubMed: 25630225 DOI: 10.1016/j.bmcl.2014.12.089 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation