4QVE

Crystal structure of Bcl-xL in complex with BID BH3 domain

4QVE の概要

• エントリーDOI: 10.2210/pdb4qve/pdb
• 関連するPDBエントリー: 1MAZ 4QVF
• 分子名称: Bcl-2-like protein 1, Peptide from BH3-interacting domain death agonist, IMIDAZOLE, ... (4 entities in total)
• 機能のキーワード: protein-peptide complex, bcl-2 like, heterodimer, apoptosis, anti-apoptotic, bh3 binding, bid bh3
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817; Cytoplasm . BH3-interacting domain death agonist p15: Mitochondrion membrane . BH3-interacting domain death agonist p13: Mitochondrion membrane . Isoform 1: Cytoplasm. Isoform 3: Cytoplasm. Isoform 2: Mitochondrion membrane: P55957
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 23075.41

構造登録者

Sreekanth, R.,Yoon, H.S. (登録日: 2014-07-14, 公開日: 2015-06-10, 最終更新日: 2023-11-08)

• 主引用文献: Rajan, S.,Choi, M.,Baek, K.,Yoon, H.S.; Bh3 induced conformational changes in Bcl-Xl revealed by crystal structure and comparative analysis.; Proteins, 83:1262-1272, 2015; PubMed: 25907960; DOI: 10.1002/prot.24816

実験手法

X-RAY DIFFRACTION (2.05 Å)