4QR7

Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation

4QR7 の概要

• エントリーDOI: 10.2210/pdb4qr7/pdb
• 関連するPDBエントリー: 4QRA 4QRB
• 分子名称: L,d-transpeptidase LdtB, GLCNAC(BETA1-4)-MURNAC(1,6-ANHYDRO)-L-ALA-GAMMA-D-GLU-MESO-A2PM-D-ALA, (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: structural genomics, enzyme function initiative, center for structural genomics of infectious diseases, csgid, l-d-transpeptidase; d-d-transpeptidase; single anomalous diffraction; imipenem; meropenem; peptidoglycan; beta-lactamase, hydrolase
• 由来する生物種: Mycobacterium tuberculosis
• 細胞内の位置: Cell membrane ; Lipid-anchor : I6Y9J2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38986.22

構造登録者

Gokulan, K.,Varughese, K.I. (登録日: 2014-06-30, 公開日: 2015-07-29, 最終更新日: 2022-02-02)

• 主引用文献: Gokulan, K.,Khare, S.,Cerniglia, C.E.,Foley, S.L.,Varughese, K.I.; Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation; To be Published,

実験手法

X-RAY DIFFRACTION (2.303 Å)