4QQD
Crystal Structure of tandem tudor domains of UHRF1 in complex with a small organic molecule
Summary for 4QQD
Entry DOI | 10.2210/pdb4qqd/pdb |
Descriptor | E3 ubiquitin-protein ligase UHRF1, 4-methyl-2,3,4,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8(1H)-imine, UNKNOWN ATOM OR ION, ... (4 entities in total) |
Functional Keywords | structural genomics, structural genomics consortium, sgc, ligase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : Q96T88 |
Total number of polymer chains | 2 |
Total formula weight | 38212.73 |
Authors | Liu, Y.,Tempel, W.,Iqbal, A.,Walker, J.R.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2014-06-27, release date: 2014-08-06, Last modification date: 2024-04-03) |
Primary citation | Liu, Y.,Iqbal, A.,Li, W.,Ni, Z.,Wang, Y.,Ramprasad, J.,Abraham, K.J.,Zhang, M.,Zhao, D.Y.,Qin, S.,Loppnau, P.,Jiang, H.,Guo, X.,Brown, P.J.,Zhen, X.,Xu, G.,Mekhail, K.,Ji, X.,Bedford, M.T.,Greenblatt, J.F.,Min, J. A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun, 13:5453-5453, 2022 Cited by PubMed: 36114190DOI: 10.1038/s41467-022-33229-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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