4QPS
Crystal structure of Jak3 complexed to N-[3-(6-Phenylamino-pyrazin-2-yl)-3H-benzoimidazol-5-yl]-acrylamide
Summary for 4QPS
Entry DOI | 10.2210/pdb4qps/pdb |
Descriptor | Tyrosine-protein kinase JAK3, N-{1-[6-(phenylamino)pyrazin-2-yl]-1H-benzimidazol-6-yl}prop-2-enamide (3 entities in total) |
Functional Keywords | kinase catalytic domain, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Endomembrane system ; Peripheral membrane protein : P52333 |
Total number of polymer chains | 2 |
Total formula weight | 67317.06 |
Authors | Argiriadi, M.A.,Goedken, E.R. (deposition date: 2014-06-24, release date: 2015-01-14, Last modification date: 2015-03-11) |
Primary citation | Goedken, E.R.,Argiriadi, M.A.,Banach, D.L.,Fiamengo, B.A.,Foley, S.E.,Frank, K.E.,George, J.S.,Harris, C.M.,Hobson, A.D.,Ihle, D.C.,Marcotte, D.,Merta, P.J.,Michalak, M.E.,Murdock, S.E.,Tomlinson, M.J.,Voss, J.W. Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol. J.Biol.Chem., 290:4573-4589, 2015 Cited by PubMed: 25552479DOI: 10.1074/jbc.M114.595181 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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