4QPS

Crystal structure of Jak3 complexed to N-[3-(6-Phenylamino-pyrazin-2-yl)-3H-benzoimidazol-5-yl]-acrylamide

Summary for 4QPS

Entry DOI	10.2210/pdb4qps/pdb
Descriptor	Tyrosine-protein kinase JAK3, N-{1-[6-(phenylamino)pyrazin-2-yl]-1H-benzimidazol-6-yl}prop-2-enamide (3 entities in total)
Functional Keywords	kinase catalytic domain, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Endomembrane system ; Peripheral membrane protein : P52333
Total number of polymer chains	2
Total formula weight	67317.06
Authors	Argiriadi, M.A.,Goedken, E.R. (deposition date: 2014-06-24, release date: 2015-01-14, Last modification date: 2015-03-11)
Primary citation	Goedken, E.R.,Argiriadi, M.A.,Banach, D.L.,Fiamengo, B.A.,Foley, S.E.,Frank, K.E.,George, J.S.,Harris, C.M.,Hobson, A.D.,Ihle, D.C.,Marcotte, D.,Merta, P.J.,Michalak, M.E.,Murdock, S.E.,Tomlinson, M.J.,Voss, J.W. Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol. J.Biol.Chem., 290:4573-4589, 2015 Cited by PubMed: 25552479 DOI: 10.1074/jbc.M114.595181 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation