4QPS

Crystal structure of Jak3 complexed to N-[3-(6-Phenylamino-pyrazin-2-yl)-3H-benzoimidazol-5-yl]-acrylamide

4QPS の概要

• エントリーDOI: 10.2210/pdb4qps/pdb
• 分子名称: Tyrosine-protein kinase JAK3, N-{1-[6-(phenylamino)pyrazin-2-yl]-1H-benzimidazol-6-yl}prop-2-enamide (3 entities in total)
• 機能のキーワード: kinase catalytic domain, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endomembrane system ; Peripheral membrane protein : P52333
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67317.06

構造登録者

Argiriadi, M.A.,Goedken, E.R. (登録日: 2014-06-24, 公開日: 2015-01-14, 最終更新日: 2015-03-11)

• 主引用文献: Goedken, E.R.,Argiriadi, M.A.,Banach, D.L.,Fiamengo, B.A.,Foley, S.E.,Frank, K.E.,George, J.S.,Harris, C.M.,Hobson, A.D.,Ihle, D.C.,Marcotte, D.,Merta, P.J.,Michalak, M.E.,Murdock, S.E.,Tomlinson, M.J.,Voss, J.W.; Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol.; J.Biol.Chem., 290:4573-4589, 2015; PubMed: 25552479; DOI: 10.1074/jbc.M114.595181

実験手法

X-RAY DIFFRACTION (1.8 Å)