4QPP

The Crystal Structure of Human HMT1 hnRNP methyltransferase-like protein 6 in complex with compound DS-421 (2-{4-[3-CHLORO-2-(2-METHOXYPHENYL)-1H-INDOL-5-YL]PIPERIDIN-1-YL}-N-METHYLETHANAMINE

Summary for 4QPP

• Entry DOI: 10.2210/pdb4qpp/pdb
• Descriptor: Protein arginine N-methyltransferase 6, POLY-UNK, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total)
• Functional Keywords: hrmt1l6, methyltransferase-like protein, structural genomics, structural genomics consortium, sgc, transferase, ds421, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : Q96LA8
• Total number of polymer chains: 6
• Total formula weight: 130411.98

Authors

Dong, A.,Zeng, H.,Smil, D.,Walker, J.R.,He, H.,Eram, M.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Vedadi, M.,Brown, P.J.,Wu, H.,Structural Genomics Consortium (SGC) (deposition date: 2014-06-24, release date: 2014-08-20, Last modification date: 2024-03-13)

• Primary citation: Zeng, H.,Dong, A.,Smil, D.,Walker, J.R.,He, H.,Eram, M.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Vedadi, M.,Brown, P.J.,Wu, H.; The Crystal Structure of Human HMT1 hnRNP methyltransferase-like protein 6 in complex with compound DS-421; To be Published,

Experimental method

X-RAY DIFFRACTION (2.52 Å)