4QO4
co-crystal structure of MDM2 (17-111) with compound 16, {(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-(6-CYCLOPROPYLPYRIDIN-2-YL)PROPYL]-3-METHYL-2-OXOPIPERIDIN-3-YL}ACETIC ACID
Summary for 4QO4
Entry DOI | 10.2210/pdb4qo4/pdb |
Related | 4QOC |
Descriptor | E3 ubiquitin-protein ligase Mdm2, {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(1S)-1-(6-cyclopropylpyridin-2-yl)propyl]-3-methyl-2-oxopiperidin-3-yl}acetic acid (3 entities in total) |
Functional Keywords | mdm2, p53, protein-protein interaction, inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleoplasm: Q00987 |
Total number of polymer chains | 1 |
Total formula weight | 11707.56 |
Authors | Huang, X. (deposition date: 2014-06-19, release date: 2014-07-16, Last modification date: 2024-02-28) |
Primary citation | Yu, M.,Wang, Y.,Zhu, J.,Bartberger, M.D.,Canon, J.,Chen, A.,Chow, D.,Eksterowicz, J.,Fox, B.,Fu, J.,Gribble, M.,Huang, X.,Li, Z.,Liu, J.J.,Lo, M.C.,McMinn, D.,Oliner, J.D.,Osgood, T.,Rew, Y.,Saiki, A.Y.,Shaffer, P.,Yan, X.,Ye, Q.,Yu, D.,Zhao, X.,Zhou, J.,Olson, S.H.,Medina, J.C.,Sun, D. Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction. ACS Med Chem Lett, 5:894-899, 2014 Cited by PubMed: 25147610DOI: 10.1021/ml500142b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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