4QNB

Disulfide stabilized HIV-1 CA hexamer in complex with PHENYL-L-PHENYLALANINAMIDE inhibitor

4QNB の概要

• エントリーDOI: 10.2210/pdb4qnb/pdb
• 関連するPDBエントリー: 3h47
• 分子名称: CAPSID PROTEIN P24, N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE (3 entities in total)
• 機能のキーワード: capsid protein, disulfide crosslink, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE) (HIV-1)
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P12497
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25886.79

構造登録者

Pornillos, O. (登録日: 2014-06-17, 公開日: 2014-12-31, 最終更新日: 2023-09-20)

• 主引用文献: Bhattacharya, A.,Alam, S.L.,Fricke, T.,Zadrozny, K.,Sedzicki, J.,Taylor, A.B.,Demeler, B.,Pornillos, O.,Ganser-Pornillos, B.K.,Diaz-Griffero, F.,Ivanov, D.N.,Yeager, M.; Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.; Proc.Natl.Acad.Sci.USA, 111:18625-18630, 2014; PubMed: 25518861; DOI: 10.1073/pnas.1419945112

実験手法

X-RAY DIFFRACTION (1.996 Å)