4QLT
yCP in complex with tripeptidic epoxyketone inhibitor 2 (PR924)
Summary for 4QLT
Entry DOI | 10.2210/pdb4qlt/pdb |
Related | 1G65 1RYP 4QLQ 4QLS 4QLU 4QLV |
Descriptor | Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (18 entities in total) |
Functional Keywords | proteasome, epoxyketone, immunoproteasome inhibitor, binding analysis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Saccharomyces cerevisiae (Baker's yeast) More |
Cellular location | Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 |
Total number of polymer chains | 28 |
Total formula weight | 732877.16 |
Authors | de Bruin, G.,Huber, E.,Xin, B.,van Rooden, E.,Al-Ayed, K.,Kim, K.,Kisselev, A.,Driessen, C.,van der Marel, G.,Groll, M.,Overkleeft, H. (deposition date: 2014-06-13, release date: 2014-07-23, Last modification date: 2023-11-08) |
Primary citation | De Bruin, G.,Huber, E.M.,Xin, B.T.,Van Rooden, E.J.,Al-Ayed, K.,Kim, K.B.,Kisselev, A.F.,Driessen, C.,Van der Stelt, M.,Van der Marel, G.A.,Groll, M.,Overkleeft, H.S. Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes J.Med.Chem., 57:6197-6209, 2014 Cited by PubMed: 25006746DOI: 10.1021/jm500716s PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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