4QLE
Crystal structure of I14A DHFR mutant complexed with folate and NADP+
Summary for 4QLE
Entry DOI | 10.2210/pdb4qle/pdb |
Related | 4QLF 4QLG |
Descriptor | Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
Functional Keywords | dihydrofolate-reductase like fold/alpha and beta proteins (a/b), oxidoreductase activity, nadp(h) binding, oxidoreductase |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 38324.12 |
Authors | Stojkovic, V.,Gakhar, L.,Kohen, A. (deposition date: 2014-06-12, release date: 2014-11-26, Last modification date: 2023-09-20) |
Primary citation | Doron, D.,Stojkovic, V.,Gakhar, L.,Vardi-Kilshtain, A.,Kohen, A.,Major, D.T. Free energy simulations of active-site mutants of dihydrofolate reductase. J.Phys.Chem.B, 119:906-916, 2015 Cited by PubMed: 25382260DOI: 10.1021/jp5059963 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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