4QL8
Crystal structure of Androgen Receptor in complex with the ligand
Summary for 4QL8
Entry DOI | 10.2210/pdb4ql8/pdb |
Descriptor | Androgen receptor, 2-chloro-4-[(3S,3aS,4S)-4-hydroxy-3-methoxy-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl]-3-methylbenzonitrile (3 entities in total) |
Functional Keywords | transcription regulation, receptor, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P10275 |
Total number of polymer chains | 1 |
Total formula weight | 30456.98 |
Authors | Krishnamurthy, N.,Sangeetha, R.,Ghadiyaram, C.,Sasmal, S.,Subramanya, H.S. (deposition date: 2014-06-11, release date: 2015-06-17, Last modification date: 2023-11-08) |
Primary citation | Ullrich, T.,Sasmal, S.,Boorgu, V.,Pasagadi, S.,Cheera, S.,Rajagopalan, S.,Bhumireddy, A.,Shashikumar, D.,Chelur, S.,Belliappa, C.,Pandit, C.,Krishnamurthy, N.,Mukherjee, S.,Ramanathan, A.,Ghadiyaram, C.,Ramachandra, M.,Santos, P.G.,Lagu, B.,Bock, M.G.,Perrone, M.H.,Weiler, S.,Keller, H. 3-alkoxy-pyrrolo[1,2-b]pyrazolines as selective androgen receptor modulators with ideal physicochemical properties for transdermal administration J.Med.Chem., 57:7396-7411, 2014 Cited by PubMed: 25121964DOI: 10.1021/jm5009049 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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