4QL8

Crystal structure of Androgen Receptor in complex with the ligand

4QL8 の概要

• エントリーDOI: 10.2210/pdb4ql8/pdb
• 分子名称: Androgen receptor, 2-chloro-4-[(3S,3aS,4S)-4-hydroxy-3-methoxy-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl]-3-methylbenzonitrile (3 entities in total)
• 機能のキーワード: transcription regulation, receptor, transcription
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P10275
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30456.98

構造登録者

Krishnamurthy, N.,Sangeetha, R.,Ghadiyaram, C.,Sasmal, S.,Subramanya, H.S. (登録日: 2014-06-11, 公開日: 2015-06-17, 最終更新日: 2023-11-08)

• 主引用文献: Ullrich, T.,Sasmal, S.,Boorgu, V.,Pasagadi, S.,Cheera, S.,Rajagopalan, S.,Bhumireddy, A.,Shashikumar, D.,Chelur, S.,Belliappa, C.,Pandit, C.,Krishnamurthy, N.,Mukherjee, S.,Ramanathan, A.,Ghadiyaram, C.,Ramachandra, M.,Santos, P.G.,Lagu, B.,Bock, M.G.,Perrone, M.H.,Weiler, S.,Keller, H.; 3-alkoxy-pyrrolo[1,2-b]pyrazolines as selective androgen receptor modulators with ideal physicochemical properties for transdermal administration; J.Med.Chem., 57:7396-7411, 2014; PubMed: 25121964; DOI: 10.1021/jm5009049

実験手法

X-RAY DIFFRACTION (2.1 Å)