4QKZ
X-ray structure of the catalytic domain of MMP-8 with the inhibitor ML115
Summary for 4QKZ
Entry DOI | 10.2210/pdb4qkz/pdb |
Descriptor | Neutrophil collagenase, CALCIUM ION, ZINC ION, ... (6 entities in total) |
Functional Keywords | hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasmic granule: P22894 |
Total number of polymer chains | 1 |
Total formula weight | 18925.23 |
Authors | Pochetti, G.,Montanari, R.,Capelli, D.,Tortorella, P. (deposition date: 2014-06-10, release date: 2015-06-17, Last modification date: 2023-11-08) |
Primary citation | Laghezza, A.,Piemontese, L.,Brunetti, L.,Caradonna, A.,Agamennone, M.,Di Pizio, A.,Pochetti, G.,Montanari, R.,Capelli, D.,Tauro, M.,Loiodice, F.,Tortorella, P. Bone-Seeking Matrix Metalloproteinase Inhibitors for the Treatment of Skeletal Malignancy. Pharmaceuticals, 13:-, 2020 Cited by PubMed: 32492898DOI: 10.3390/ph13060113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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