4QKH

Dimeric form of human LLT1, a ligand for NKR-P1

4QKH の概要

• エントリーDOI: 10.2210/pdb4qkh/pdb
• 関連するPDBエントリー: 4QKG 4QKI 4QKJ
• 分子名称: C-type lectin domain family 2 member D, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: c-type lectin like fold, ligand for human receptor nkr-p1, glycosylation; deglycosylated after the first glcnac unit, anchored in membrane on cell surface, immune system
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32269.56

構造登録者

Skalova, T.,Blaha, J.,Harlos, K.,Duskova, J.,Koval, T.,Stransky, J.,Hasek, J.,Vanek, O.,Dohnalek, J. (登録日: 2014-06-06, 公開日: 2015-03-11, 最終更新日: 2024-10-16)

主引用文献

Skalova, T.,Blaha, J.,Harlos, K.,Duskova, J.,Koval, T.,Stransky, J.,Hasek, J.,Vanek, O.,Dohnalek, J.
Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states
Acta Crystallogr.,Sect.D, 71:578-591, 2015

PubMed Abstract: Human LLT1 is a C-type lectin-like ligand of NKR-P1 (CD161, gene KLRB1), a C-type lectin-like receptor of natural killer cells. Using X-ray diffraction, the first experimental structures of human LLT1 were determined. Four structures of LLT1 under various conditions were determined: monomeric, dimeric deglycosylated after the first N-acetylglucosamine unit in two forms and hexameric with homogeneous GlcNAc2Man5 glycosylation. The dimeric form follows the classical dimerization mode of human CD69. The monomeric form keeps the same fold with the exception of the position of an outer part of the long loop region. The hexamer of glycosylated LLT1 consists of three classical dimers. The hexameric packing may indicate a possible mode of interaction of C-type lectin-like proteins in the glycosylated form.

PubMed: 25760607
DOI: 10.1107/S1399004714027928

実験手法

X-RAY DIFFRACTION (1.8 Å)