4QJW
Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with inhibitor
Summary for 4QJW
Entry DOI | 10.2210/pdb4qjw/pdb |
Related | 4QIY 4QIZ 4QJ0 4QJM 4QJO 4QJP 4QJX 4QTL |
Descriptor | Carbonic anhydrase 12, ZINC ION, 3-(benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide, ... (5 entities in total) |
Functional Keywords | drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: O43570 |
Total number of polymer chains | 4 |
Total formula weight | 122063.04 |
Authors | Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2014-06-05, release date: 2015-04-15, Last modification date: 2023-11-08) |
Primary citation | Dudutiene, V.,Zubriene, A.,Smirnov, A.,Timm, D.D.,Smirnoviene, J.,Kazokaite, J.,Michailoviene, V.,Zaksauskas, A.,Manakova, E.,Grazulis, S.,Matulis, D. Functionalization of Fluorinated Benzenesulfonamides and Their Inhibitory Properties toward Carbonic Anhydrases Chemmedchem, 10:662-687, 2015 Cited by PubMed: 25758852DOI: 10.1002/cmdc.201402490 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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